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KMID : 0380620130450010084
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Korean Journal of Food Science and Technology
2013 Volume.45 No. 1 p.84 ~ p.89
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Total Phenolics of Dried Platycodon grandiflorum and Its Effect on Growth of Human Cancer Cell Lines
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Hwang Seong-Yeon
Choi Hyang-Mi
Lim Sun-Young
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Abstract
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We investigated the effects of extracts from dried Platycodon grandiflorum on total phenolic content and
growth of cancer cell lines (HT-29 and AGS). Total phenolic contents of acetone/methylene chloride (A+M) extract and
methanol (MeOH) fraction were 4.53 and 27.22 TAE mg/100 g, respectively. Among the fractions, n-butanol (n-BuOH)
fraction contained the highest phenolic content. Treatments of crude extracts and fractions significantly inhibited the growth
of HT-29 and AGS cancer cell lines (p<0.05). Among the fractions, n-BuOH fraction exhibited the highest inhibitory
effect and was then sub-fractionated by reverse phase flash column chromatography (rfc). The rfc 1-3 exhibited a higher
inhibitory effect on proliferation of both cancer cells. The rfc 1 contained the highest phenol content. Our results showed
that n-BuOH fraction possessed a potent inhibitory effect on proliferation of human cancer cells. We suggested that this
anticancer activity was partially related to the content of phenolic compounds.
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KEYWORD
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Platycodon grandiflorum, total phenol content, human cancer cell, growth inhibition, anticancer
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